Basic Information:

Symbol	FYCO1
Synonyms	ZFYVE7
Protein Name	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7)
Species	Human
Entrez ID	79443
Uniprot ID	Q9BQS8
Membrane Contact Site	ER-Endosome; Endosome-ER
Location (from literature)	Endosome
Cell line/Tissue	HeLa cells; hTERT-RPE1 cells; HL60 cells; HEK293 cells
Experimental Method	Low throughput experimental methods
Protein Sequence
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Complex Information:

Complex ID	Subunit of complex	Subcellular location	Species	More
CMCS00006	ZFYVE27; FYCO1; KIF5B; RAB7A; PI(3)P	ER-Endosome; Endosome-ER	Human	more

Expression Overview of FYCO1:

Homology Information of FYCO1:

Uniprot ID	Q9BQS8
EggNOG	KOG1729
HOGENOM	CLU_004445_0_0_1
OrthoDB	5394846at2759
TreeFam	TF341788
GeneTree	ENSGT00940000154044

References:

Pubmed ID	25855459
DOI	10.1038/nature14359
Description	Here we show in human and rat cell lines that protrudin, an ER protein that promotes protrusion and neurite outgrowth, forms contact sites with late endosomes (LEs) via coincident detection of the small GTPase RAB7 and phosphatidylinositol 3-phosphate (PtdIns(3)P). These contact sites mediate transfer of the microtubule motor kinesin 1 from protrudin to the motor adaptor FYCO1 on LEs.
Description of experimental evidence	The protein was validated by microscopy, western blotting, GFP-trap assay in HeLa cells, HEK293 cells; hTERT-RPE1 cells and HL60 cells, and these results correlate strongly with the cooperative effects of protrudin and FYCO1 in protrusion and neurite outgrowth.
More related results