Detail Information

P450 Protein:

P450 SymbolCYP71D495
Protein NameCasbene 9-oxidase
Uniprot IDA0A191VYX7
SpeciesJatropha curcas (Barbados nut)
Txid 180498
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location/
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C28H30O2 → C20H28O3
Reaction TypeOxidation
Chemical BondCH2

6-Hydroxy-5-Keto-Casbene

CYP71D495

6-Hydroxy-5,9-Diketocasbene

Substrate Information:

Substrate Name 6-Hydroxy-5-Keto-Casbene
Substrate Chemical FormulaC28H30O2
Substrate Smiles[C@H](O)1C(=O)/C(/C)=C/[C@]([H])2[C@@](C)(C)[C@@]2([H])CC/C(/C)=C/CC/C(/C)=C/1
Substrate Structure

Product Information:

Product Name 6-Hydroxy-5,9-Diketocasbene
Product Chemical FormulaC20H28O3
Product SmilesO=C1/C(/C)=C/[C@]2([C@@](C)(C)[C@@]2([H])CC/C(/C)=C/CC(=O)/C(/C)=C/[C@@H]1O)[H]
Product Structure

References:

Title: A Cytochrome P450-Mediated Intramolecular Carbon-Carbon Ring Closure in the Biosynthesis of Multidrug-Resistance-Reversing Lathyrane Diterpenoids.
PMID: 27272333
Journal: Chembiochem : a European journal of chemical biology
Year: 2016/9/2

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics