Detail Information
P450 Protein:
| P450 Symbol | CYP81AA1 |
| Protein Name | 1,3,7-trihydroxyxanthone synthase |
| Uniprot ID | A0A168GPG9 |
| Species | Hypericum perforatum (St. John's wort) |
| Txid | 65561 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C13H10O5 → C13H8O5 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP81AA1
Substrate Information:
| Substrate Name | 2,3′,4,6-Tetrahydroxybenzophenone |
| Substrate Chemical Formula | C13H10O5 |
| Substrate PubChem CID | 440991 |
| Substrate Smiles | C1=CC(=CC(=C1)O)C(=O)C2=C(C=C(C=C2O)O)O |
| Substrate Structure |
Product Information:
| Product Name | 1,3,7-Trihydroxyxanthone |
| Product Chemical Formula | C13H8O5 |
| Product PubChem CID | 5281635 |
| Product Smiles | C1=CC2=C(C=C1O)C(=O)C3=C(C=C(C=C3O2)O)O |
| Product Structure |
References:
| Title: | Bifunctional CYP81AA proteins catalyse identical hydroxylations but alternative regioselective phenol couplings in plant xanthone biosynthesis. |
| PMID: | 27145837 |
| Journal: | Nature communications |
| Year: | 2016/5/5 |