Detail Information

P450 Protein:

P450 SymbolCYP76AH15
Protein NameCytochrome P450 CYP76AH15
Uniprot IDA0A1B0VRQ0
SpeciesPlectranthus barbatus
Txid 41228
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular LocationEndoplasmic reticulum membrane; Single-pass membrane protein Microsome membrane; Single-pass membrane protein
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C20H34O → C20H32O2
Reaction TypeOxidation
Chemical BondCH

13(R)-Manoyl Oxide

CYP76AH15

(3R,4aR,6aS,10aS)-3-ethenyl-3,4a,7,7,10a-pentamethyl-2,5,6,6a,8,9,10,10b-octahydrobenzo[f]chromen-1-one

Substrate Information:

Substrate Name 13(R)-Manoyl Oxide
Substrate Chemical FormulaC20H34O
Substrate PubChem CID6432025
Substrate SmilesC[C@@]1(CC[C@@H]2[C@]3(CCCC([C@@H]3CC[C@]2(O1)C)(C)C)C)C=C
Substrate Structure

Product Information:

Product Name (3R,4aR,6aS,10aS)-3-ethenyl-3,4a,7,7,10a-pentamethyl-2,5,6,6a,8,9,10,10b-octahydrobenzo[f]chromen-1-one
Product Chemical FormulaC20H32O2
Product PubChem CID101529309
Product SmilesC1C[C@@](C)2C3C(=O)C[C@@](C=C)(C)O[C@]3(C)CC[C@@]2([H])C(C)(C)C1
Product Structure

References:

Title: Engineering of CYP76AH15 can improve activity and specificity towards forskolin biosynthesis in yeast.
PMID: 30453976
Journal: Microbial cell factories
Year: 2018/11/19

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics