Detail Information
P450 Protein:
| P450 Symbol | CYP76AH15 |
| Protein Name | Cytochrome P450 CYP76AH15 |
| Uniprot ID | A0A1B0VRQ0 |
| Species | Plectranthus barbatus |
| Txid | 41228 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Microsome membrane; Peripheral membrane protein Endoplasmic reticulum membrane; Peripheral membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H30 → C20H30O |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP76AH15
Substrate Information:
| Substrate Name | Abietatriene |
| Substrate Chemical Formula | C20H30 |
| Substrate PubChem CID | 6432211 |
| Substrate CAS Number | 19407-28-4 |
| Substrate Smiles | CC(C)C1=CC2=C(C=C1)[C@]3(CCCC([C@@H]3CC2)(C)C)C |
| Substrate Structure |
Product Information:
| Product Name | trans-Ferruginol |
| Product Chemical Formula | C20H30O |
| Product PubChem CID | 442027 |
| Product Smiles | C1C[C@@](C)2C3C=C(O)C(C(C)C)=CC=3CC[C@@]2([H])C(C)(C)C1 |
| Product Structure |
References:
| Title: | Engineering of CYP76AH15 can improve activity and specificity towards forskolin biosynthesis in yeast. |
| PMID: | 30453976 |
| Journal: | Microbial cell factories |
| Year: | 2018/11/19 |