Detail Information
P450 Protein:
| P450 Symbol | CYP76AH11 |
| Protein Name | Cytochrome P450 CYP76AH11 |
| Uniprot ID | A0A1B0VRN6 |
| Species | Plectranthus barbatus |
| Txid | 41228 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein Microsome membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H32O2 → C20H32O5 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP76AH11
Substrate Information:
| Substrate Name | (3R,4aR,6aS,10aS)-3-ethenyl-3,4a,7,7,10a-pentamethyl-2,5,6,6a,8,9,10,10b-octahydrobenzo[f]chromen-1-one |
| Substrate Chemical Formula | C20H32O2 |
| Substrate PubChem CID | 101529309 |
| Substrate Smiles | C1C[C@@](C)2C3C(=O)C[C@@](C=C)(C)O[C@]3(C)CC[C@@]2([H])C(C)(C)C1 |
| Substrate Structure |
Product Information:
| Product Name | 9-deoxy-7-deacetylforskolin |
| Product Chemical Formula | C20H32O5 |
| Product PubChem CID | 24113327 |
| Product Smiles | C1[C@H](O)[C@@](C)2C3C(=O)C[C@@](C=C)(C)O[C@]3(C)[C@@H](O)[C@@H](O)[C@@]2([H])C(C)(C)C1 |
| Product Structure |
References:
| Title: | Engineering of CYP76AH15 can improve activity and specificity towards forskolin biosynthesis in yeast. |
| PMID: | 30453976 |
| Journal: | Microbial cell factories |
| Year: | 2018/11/19 |