Detail Information

P450 Protein:

P450 SymbolCYP716A83
Protein NameBeta-amyrin 28-oxidase
Uniprot IDA0A1I9Q5Y4
SpeciesCentella asiatica
Txid 48106
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location/
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C30H50O2 → C30H48O3
Reaction TypeOxidation
Chemical BondCH2-OH

Uvaol

CYP716A83

Ursolic Acid

Substrate Information:

Substrate Name Uvaol
Substrate Chemical FormulaC30H50O2
Substrate PubChem CID92802
Substrate SmilesC[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)[C@@H]2[C@H]1C)C)CO
Substrate Structure

Product Information:

Product Name Ursolic Acid
Product Chemical FormulaC30H48O3
Product PubChem CID64945
Product SmilesC[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)[C@@H]2[C@H]1C)C)C(=O)O
Product Structure

References:

Title: The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis.
PMID: 28165039
Journal: Nature communications
Year: 2017/2/6

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
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