Detail Information

P450 Protein:

P450 SymbolCYP716E41
Protein NameOleanolic acid 6-beta-oxidase
Uniprot IDA0A1I9Q5Y6
SpeciesCentella asiatica
Txid 48106
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location/
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C30H48O3 → C30H48O4
Reaction TypeOxidation
Chemical BondCH2

Oleanolic Acid

CYP716E41

6Beta-Hydroxy-Oleanolic Acid

Substrate Information:

Substrate Name Oleanolic Acid
Substrate Chemical FormulaC30H48O3
Substrate PubChem CID10494
Substrate SmilesC[C@]12CC[C@@H](C([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)C)(C)C)O
Substrate Structure

Product Information:

Product Name 6Beta-Hydroxy-Oleanolic Acid
Product Chemical FormulaC30H48O4
Product PubChem CID12443148
Product SmilesC[C@]12CC[C@@H](C([C@@H]1[C@@H](C[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)C)O)(C)C)O
Product Structure

References:

Title: The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis.
PMID: 28165039
Journal: Nature communications
Year: 2017/2/6

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
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