Detail Information

P450 Protein:

P450 SymbolCYP716A140
Protein NameBeta-amyrin 28-oxidase
Uniprot IDA0A1I9Q5Y8
SpeciesPlatycodon grandiflorus (Balloon flower) (Campanula grandiflora)
Txid 94286
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular LocationMembrane; Single-pass membrane protein
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C30H48O4 → C30H48O4
Reaction TypeOxidation
Chemical BondCH3

12,13Alpha-Epoxyoleanolic Acid

CYP716A140

12Alpha-Hydroxy-Beta-Amyrin-13,28Beta-Lactone

Substrate Information:

Substrate Name 12,13Alpha-Epoxyoleanolic Acid
Substrate Chemical FormulaC30H48O4
Substrate SmilesC1C[C@@](C)2C3C[C@@H]4O[C@@]44C5C[C@](C)(C)CC[C@]5(C(O)=O)CC[C@@]4(C)[C@]3(C)CCC2[C@@](C)(C)[C@H]1O
Substrate Structure

Product Information:

Product Name 12Alpha-Hydroxy-Beta-Amyrin-13,28Beta-Lactone
Product Chemical FormulaC30H48O4
Product PubChem CID57329383
Product SmilesC1C[C@@](C)2C3C[C@H](O)[C@]45OC(=O)[C@@]6(CC[C@](C)(C)CC46)CC[C@@]5(C)[C@]3(C)CCC2[C@@](C)(C)[C@H]1O
Product Structure

References:

Title: The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis.
PMID: 28165039
Journal: Nature communications
Year: 2017/2/6

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
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