Detail Information
P450 Protein:
| P450 Symbol | CYP154C8 |
| Protein Name | Steroid hydroxylase CYP154C8 |
| Uniprot ID | A0A2H4WK62 |
| Species | Streptomyces sp. |
| Txid | 1931 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | / |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C21H30O2 → C21H30O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH2 |
CYP154C8
Substrate Information:
| Substrate Name | Progesterone |
| Substrate Chemical Formula | C21H30O2 |
| Substrate PubChem CID | 5994 |
| Substrate Smiles | CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C |
| Substrate Structure |
Product Information:
| Product Name | 16Alpha-Hydroxyprogesterone |
| Product Chemical Formula | C21H30O3 |
| Product PubChem CID | 243761 |
| Product Smiles | CC(=O)[C@H]1[C@@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O |
| Product Structure |
References:
| Title: | Tracking Down a New Steroid-Hydroxylating Promiscuous Cytochrome?P450: CYP154C8 from Streptomyces sp. W2233-SM. |
| PMID: | 29512903 |
| Journal: | Chembiochem : a European journal of chemical biology |
| Year: | 2018/5/18 |