Detail Information

P450 Protein:

P450 SymbolCYP72A565
Protein NameCYP72A565
Uniprot IDA0A4Y5UJ61
SpeciesCamptotheca acuminata (Happy tree)
Txid 16922
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
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Subcellular Location/
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C17H26O10 → C17H24O10
Reaction TypeOxidation
Chemical BondCH-CH

Loganin

CYP72A565

Secologanin

Substrate Information:

Substrate Name Loganin
Substrate Chemical FormulaC17H26O10
Substrate PubChem CID87691
Substrate SmilesC[C@H]1[C@H](C[C@H]2[C@@H]1[C@@H](OC=C2C(=O)OC)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O
Substrate Structure

Product Information:

Product Name Secologanin
Product Chemical FormulaC17H24O10
Product PubChem CID161276
Product SmilesCOC(=O)C1=CO[C@H]([C@@H]([C@@H]1CC=O)C=C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O
Product Structure

References:

Title: Bifunctional Cytochrome P450 Enzymes Involved in Camptothecin Biosynthesis.
PMID: 31117393
Journal: ACS chemical biology
Year: 2019/6/21

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics