Detail Information
P450 Protein:
| P450 Symbol | CYP90B50 |
| Protein Name | Cholesterol 16,22-dihydroxylase CYP90G4 |
| Uniprot ID | A0A517FND3 |
| EC Number | 1.14.14.- |
| Species | Trigonella foenum-graecum (Fenugreek) |
| Txid | 78534 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C27H46O → C27H46O2 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP90B50
Substrate Information:
| Substrate Name | Cholesterol |
| Substrate Chemical Formula | C27H46O |
| Substrate PubChem CID | 5997 |
| Substrate Smiles | C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C |
| Substrate Structure |
Product Information:
| Product Name | 22S-hydroxycholesterol |
| Product Chemical Formula | C27H46O2 |
| Product PubChem CID | 168038 |
| Product Smiles | C1C[C@@](C)2[C@]([H])3CC[C@@](C)4[C@@]([H])([C@@H]([C@@H](O)CC[C@@H](C)C)C)CC[C@@]4([H])[C@]3([H])CC=C2C[C@H]1O |
| Product Structure |
References:
| Title: | Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants. |
| PMID: | 31324795 |
| Journal: | Nature communications |
| Year: | 2019/7/19 |