Detail Information

P450 Protein:

P450 SymbolCYP90G4
Protein NameCholesterol 16,22-dihydroxylase CYP90G4
Uniprot IDA0A517FNC5
EC Number1.14.14.-
SpeciesParis polyphylla (Daiswa polyphylla)
Txid 49666
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular LocationMembrane; Single-pass membrane protein
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C27H46O3 → C27H44O3
Reaction TypeOxidation
Chemical BondCH-OH

16S,22S-Dihydroxycholesterol

CYP90G4

(20S,22S)-3β,22-dihydroxycholestan-6(5)-en-16-one

Substrate Information:

Substrate Name 16S,22S-Dihydroxycholesterol
Substrate Chemical FormulaC27H46O3
Substrate PubChem CID91013295
Substrate SmilesC[C@@H]([C@H]1[C@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)O)[C@H](CCC(C)C)O
Substrate Structure

Product Information:

Product Name (20S,22S)-3β,22-dihydroxycholestan-6(5)-en-16-one
Product Chemical FormulaC27H44O3
Product SmilesO[C@@H](CC[C@H](C)C)[C@H]([C@@]([H])1[C@]2(CC[C@]([H])3[C@@]([H])(CC=C4C[C@H](CC[C@@]43C)O)[C@]2([H])CC1=O)C)C
Product Structure

References:

Title: Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants.
PMID: 31324795
Journal: Nature communications
Year: 2019/7/19

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
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