Detail Information
P450 Protein:
| P450 Symbol | CYP71FB1 |
| Protein Name | Cytochrome P450 family 71 subfamily FB polypeptide 1 |
| Uniprot ID | A0A7D5Q3W9 |
| Species | Gloriosa superba (Glory lily) |
| Txid | 41220 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | / |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C22H27NO5 → C22H25NO6 |
| Reaction Type | Oxidation |
| Chemical Bond | CH3 |
CYP71FB1
Substrate Information:
| Substrate Name | O-Methylandrocymbine |
| Substrate Chemical Formula | C22H27NO5 |
| Substrate PubChem CID | 15286666 |
| Substrate Smiles | CN1CC[C@@]23C=C(C(=O)C=C2[C@@H]1CCC4=CC(=C(C(=C34)OC)OC)OC)OC |
| Substrate Structure |
Product Information:
| Product Name | N-Formyldemecolcine |
| Product Chemical Formula | C22H25NO6 |
| Product PubChem CID | 26819 |
| Product Smiles | CN(C=O)[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC |
| Product Structure |
References:
| Title: | Discovery and engineering of colchicine alkaloid biosynthesis. |
| PMID: | 32699417 |
| Journal: | Nature |
| Year: | 2020/8/1 |