Detail Information
P450 Protein:
| P450 Symbol | CYP154C3 |
| Protein Name | Cytochrome P450 154C3 |
| Uniprot ID | A0A7S9IUH5 |
| Species | Streptomyces sp. |
| Txid | 1931 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | / |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C21H32O2 → C21H32O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH2 |
CYP154C3
Substrate Information:
| Substrate Name | Pregnenolone |
| Substrate Chemical Formula | C21H32O2 |
| Substrate PubChem CID | 8955 |
| Substrate Smiles | CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C |
| Substrate Structure |
Product Information:
| Product Name | 16Alpha-Hydroxypregnenolone |
| Product Chemical Formula | C21H32O3 |
| Product PubChem CID | 6452574 |
| Product Smiles | CC(=O)[C@H]1[C@@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)O |
| Product Structure |
References:
| Title: | Regio- and stereospecific hydroxylation of various steroids at the 16α position of the D ring by the Streptomyces griseus cytochrome P450 CYP154C3. |
| PMID: | 24334658 |
| Journal: | Applied and environmental microbiology |
| Year: | 2014/2/1 |