Detail Information

P450 Protein:

P450 SymbolCYP154C3
Protein NameCytochrome P450 154C3
Uniprot IDA0A7S9IUH5
SpeciesStreptomyces sp.
Txid 1931
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location/
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C19H28O2 → C19H28O3
Reaction TypeOxidation
Chemical BondCH2

Dehydroepiandrosterone

CYP154C3

16Alpha-Hydroxydehydroepiandrosterone

Substrate Information:

Substrate Name Dehydroepiandrosterone
Substrate Chemical FormulaC19H28O2
Substrate PubChem CID5881
Substrate SmilesC[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CC=C4[C@@]3(CC[C@@H](C4)O)C
Substrate Structure

Product Information:

Product Name 16Alpha-Hydroxydehydroepiandrosterone
Product Chemical FormulaC19H28O3
Product PubChem CID102030
Product SmilesC[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3C[C@H](C4=O)O)C)O
Product Structure

References:

Title: Regio- and stereospecific hydroxylation of various steroids at the 16α position of the D ring by the Streptomyces griseus cytochrome P450 CYP154C3.
PMID: 24334658
Journal: Applied and environmental microbiology
Year: 2014/2/1

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics