Detail Information

P450 Protein:

P450 Symbolcyp27c1
Protein NameCytochrome P450 27C1
Uniprot IDA8WGA0
EC Number1.14.19.53
Gene ID 558396
SpeciesDanio rerio (Zebrafish) (Brachydanio rerio)
Txid 7955
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular LocationMembrane
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C20H30O + Fe2S2 + O2 + H+ → C20H28O + Fe2S2 + H2O
Reaction TypeOxidation
Chemical BondCH2-CH2
RheaID 50292

All-Trans-Retinol

+

[2Fe-2S]1+

+

O2

+

H+

cyp27c1

All-Trans-3,4-Didehydroretinol

+

[2Fe-2S]2+

+

H2O

Substrate Information:

Substrate Name All-Trans-Retinol
Substrate Chemical FormulaC20H30O
Substrate PubChem CID445354
Substrate SmilesCC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C
Substrate Structure
Substrate Name [2Fe-2S]1+
Substrate Chemical FormulaFe2S2
Substrate SmilesS1[Fe]S[Fe+]1
Substrate Structure
Substrate Name O2
Substrate Chemical FormulaO2
Substrate PubChem CID977
Substrate CAS Number7782-44-7
Substrate SmilesO=O
Substrate Structure
Substrate Name H+
Substrate Chemical FormulaH+
Substrate PubChem CID1038
Substrate CAS Number12408-02-5
Substrate Smiles[H+]
Substrate Structure

Product Information:

Product Name All-Trans-3,4-Didehydroretinol
Product Chemical FormulaC20H28O
Product PubChem CID6436043
Product SmilesCC1=C(C(CC=C1)(C)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C
Product Structure
Product Name [2Fe-2S]2+
Product Chemical FormulaFe2S2
Product SmilesS1[Fe+]S[Fe+]1
Product Structure
Product Name H2O
Product Chemical FormulaH2O
Product PubChem CID962
Product CAS Number7732-18-5
Product SmilesO
Product Structure

References:

Title: Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2.
PMID: 26549260
Journal: Current biology : CB
Year: 2015/12/7

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics