Detail Information

P450 Protein:

P450 SymbolCYP153A16
Protein NameCytochrome P450 153A16 Cyp153A16
Uniprot IDB2HGN5
SpeciesMycobacterium marinum (strain ATCC BAA-535 / M)
Txid 216594
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location/
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C8H18 + C17H21N4O9P-2 + O2 → C8H18O + C17H18N4O9P-3 + H2O + H+
Reaction TypeOxidation
Chemical BondCH3

Octane

+

FMNH2

+

O2

CYP153A16

1-Octanol

+

FMN

+

H2O

+

H+

Substrate Information:

Substrate Name Octane
Substrate Chemical FormulaC8H18
Substrate PubChem CID356
Substrate SmilesCCCCCCCC
Substrate Structure
Substrate Name FMNH2
Substrate Chemical FormulaC17H21N4O9P-2
Substrate PubChem CID44229161
Substrate SmilesCC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O
Substrate Structure
Substrate Name O2
Substrate Chemical FormulaO2
Substrate PubChem CID977
Substrate CAS Number7782-44-7
Substrate SmilesO=O
Substrate Structure

Product Information:

Product Name 1-Octanol
Product Chemical FormulaC8H18O
Product PubChem CID957
Product SmilesCCCCCCCCO
Product Structure
Product Name FMN
Product Chemical FormulaC17H18N4O9P-3
Product PubChem CID44229199
Product SmilesCC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O
Product Structure
Product Name H2O
Product Chemical FormulaH2O
Product PubChem CID962
Product CAS Number7732-18-5
Product SmilesO
Product Structure
Product Name H+
Product Chemical FormulaH+
Product PubChem CID1038
Product CAS Number12408-02-5
Product Smiles[H+]
Product Structure

References:

Title: Regioselective ω-hydroxylation of medium-chain n-alkanes and primary alcohols by CYP153 enzymes from Mycobacterium marinum and Polaromonas sp. strain JS666.
PMID: 21837346
Journal: Organic & biomolecular chemistry
Year: 2011/10/7

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics