Detail Information
P450 Protein:
| P450 Symbol | CYP88D6 |
| Protein Name | Beta-amyrin 11-oxidase |
| Uniprot ID | B5BSX1 |
| EC Number | 1.14.14.152 |
| Species | Glycyrrhiza uralensis (Chinese licorice) (Glycyrrhiza shiheziensis) |
| Txid | 74613 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C30H50O2 → C30H48O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH2 |
CYP88D6
Substrate Information:
| Substrate Name | 30-Hydroxy-Beta-Amyrin |
| Substrate Chemical Formula | C30H50O2 |
| Substrate PubChem CID | 12801541 |
| Substrate Smiles | C[C@]12CC[C@](C[C@H]1C3=CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)CO |
| Substrate Structure |
Product Information:
| Product Name | 30-Hydroxy-11-Oxo-Beta-Amyrin |
| Product Chemical Formula | C30H48O3 |
| Product PubChem CID | 12310283 |
| Product Smiles | C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)CO |
| Product Structure |
References:
| Title: | Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin. |
| PMID: | 18779566 |
| Journal: | Proceedings of the National Academy of Sciences of the United States of America |
| Year: | 2008/9/16 |