Detail Information
P450 Protein:
| P450 Symbol | CYP107BR1 |
| Protein Name | Vitamin D(3) 25-hydroxylase |
| Uniprot ID | C4B644 |
| EC Number | 1.14.15.15 |
| Species | Pseudonocardia autotrophica (Amycolata autotrophica) (Nocardia autotrophica) |
| Txid | 2074 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Cytoplasm |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C27H44O → C27H44O2 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP107BR1
Substrate Information:
| Substrate Name | Vitamin D3 |
| Substrate Chemical Formula | C27H44O |
| Substrate PubChem CID | 5280795 |
| Substrate Smiles | C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CCC/C2=CC=C/3C[C@H](CCC3=C)O)C |
| Substrate Structure |
Product Information:
| Product Name | Calcidiol |
| Product Chemical Formula | C27H44O2 |
| Product PubChem CID | 5283731 |
| Product Smiles | C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]2[C@@]1(CCC/C2=CC=C/3C[C@H](CCC3=C)O)C |
| Product Structure |
References:
| Title: | Purification, characterization, and directed evolution study of a vitamin D3 hydroxylase from Pseudonocardia autotrophica. |
| PMID: | 19450562 |
| Journal: | Biochemical and biophysical research communications |
| Year: | 2009/7/24 |