Detail Information
P450 Protein:
| P450 Symbol | CYP109E1 |
| Protein Name | Cytochrome P450 |
| Uniprot ID | D5DKI8 |
| EC Number | 1.14.14.- |
| Species | Bacillus megaterium (strain DSM 319 / IMG 1521) |
| Txid | 592022 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | / |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C19H28O2 → C19H28O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH2 |
CYP109E1
Substrate Information:
| Substrate Name | Testosterone |
| Substrate Chemical Formula | C19H28O2 |
| Substrate PubChem CID | 6013 |
| Substrate Smiles | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=O)CC[C@]34C |
| Substrate Structure |
Product Information:
| Product Name | 16Beta-Hydroxytestosterone |
| Product Chemical Formula | C19H28O3 |
| Product PubChem CID | 15708880 |
| Product Smiles | C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3C[C@@H]([C@@H]4O)O)C |
| Product Structure |
References:
| Title: | Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 from Bacillus megaterium. |
| PMID: | 27686671 |
| Journal: | The FEBS journal |
| Year: | 2016/11/1 |