Detail Information

P450 Protein:

P450 SymbolBMQ_pBM50008
Protein NameCytochrome P450 CYP107DY1
Uniprot IDD5E3H2
EC Number1.14.-.-
SpeciesBacillus megaterium (strain ATCC 12872 / QMB1551)
Txid 545693
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location/
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C23H34O5 + Fe2S2 + O2 + H+ → C23H34O6 + Fe2S2 + H2O
Reaction TypeOxidation
Chemical BondCH2
RheaID 51668

Mevastatin

+

[2Fe-2S]1+

+

O2

+

H+

BMQ_pBM50008

Pravastatin Lactone

+

[2Fe-2S]2+

+

H2O

Substrate Information:

Substrate Name Mevastatin
Substrate Chemical FormulaC23H34O5
Substrate PubChem CID64715
Substrate SmilesCC[C@H](C)C(=O)O[C@H]1CCC=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O
Substrate Structure
Substrate Name [2Fe-2S]1+
Substrate Chemical FormulaFe2S2
Substrate SmilesS1[Fe]S[Fe+]1
Substrate Structure
Substrate Name O2
Substrate Chemical FormulaO2
Substrate PubChem CID977
Substrate CAS Number7782-44-7
Substrate SmilesO=O
Substrate Structure
Substrate Name H+
Substrate Chemical FormulaH+
Substrate PubChem CID1038
Substrate CAS Number12408-02-5
Substrate Smiles[H+]
Substrate Structure

Product Information:

Product Name Pravastatin Lactone
Product Chemical FormulaC23H34O6
Product PubChem CID9931182
Product SmilesCC[C@H](C)C(=O)O[C@H]1C[C@@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)O
Product Structure
Product Name [2Fe-2S]2+
Product Chemical FormulaFe2S2
Product SmilesS1[Fe+]S[Fe+]1
Product Structure
Product Name H2O
Product Chemical FormulaH2O
Product PubChem CID962
Product CAS Number7732-18-5
Product SmilesO
Product Structure

References:

Title: Identification of a new plasmid-encoded cytochrome P450 CYP107DY1 from Bacillus megaterium with a catalytic activity towards mevastatin.
PMID: 27816653
Journal: Journal of biotechnology
Year: 2016/12/20

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics