Detail Information

P450 Protein:

P450 SymbolCYP72A63
Protein Name11-oxo-beta-amyrin 30-oxidase
Uniprot IDH1A981
EC Number1.14.14.115
SpeciesMedicago truncatula (Barrel medic) (Medicago tribuloides)
Txid 3880
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular LocationMembrane; Single-pass membrane protein
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C30H50O2 → C30H48O3
Reaction TypeOxidation
Chemical BondCH2-OH

30-Hydroxy-Beta-Amyrin

CYP72A63

11-Deoxoglycyrrhetinic Acid

Substrate Information:

Substrate Name 30-Hydroxy-Beta-Amyrin
Substrate Chemical FormulaC30H50O2
Substrate PubChem CID12801541
Substrate SmilesC[C@]12CC[C@](C[C@H]1C3=CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)CO
Substrate Structure

Product Information:

Product Name 11-Deoxoglycyrrhetinic Acid
Product Chemical FormulaC30H48O3
Product PubChem CID12305517
Product SmilesC[C@]12CC[C@](C[C@H]1C3=CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)O
Product Structure

References:

Title: Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin.
PMID: 22128119
Journal: The Plant cell
Year: 2011/11/1

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics