Detail Information
P450 Protein:
| P450 Symbol | CYP72A61v2 |
| Protein Name | Cytochrome P450 monooxygenase |
| Uniprot ID | H1A985 |
| Species | Medicago truncatula (Barrel medic) (Medicago tribuloides) |
| Txid | 3880 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C30H48O4 → C30H46O5 |
| Reaction Type | Oxidation |
| Chemical Bond | CH2-OH |
CYP72A61v2
Substrate Information:
| Substrate Name | Hederagenin |
| Substrate Chemical Formula | C30H48O4 |
| Substrate PubChem CID | 73299 |
| Substrate Smiles | C[C@]12CC[C@@H]([C@@]([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)C)(C)CO)O |
| Substrate Structure |
Product Information:
| Product Name | Gypsogenic Acid |
| Product Chemical Formula | C30H46O5 |
| Product PubChem CID | 15560324 |
| Product Smiles | C[C@]12CC[C@@H]([C@@]([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)C)(C)C(=O)O)O |
| Product Structure |
References:
| Title: | Combinatorial biosynthesis of legume natural and rare triterpenoids in engineered yeast. |
| PMID: | 23378447 |
| Journal: | Plant & cell physiology |
| Year: | 2013/5/1 |
| Title: | CYP72A67 Catalyzes a Key Oxidative Step in Medicago truncatula Hemolytic Saponin Biosynthesis. |
| PMID: | 26079384 |
| Journal: | Molecular plant |
| Year: | 2015/10/5 |