Detail Information
P450 Protein:
| P450 Symbol | CYP716A47 |
| Protein Name | Dammarenediol 12-hydroxylase |
| Uniprot ID | H2DH16 |
| EC Number | 1.14.14.120 |
| Species | Panax ginseng (Korean ginseng) |
| Txid | 4054 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C30H52O2 → C30H52O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH2 |
CYP716A47
Substrate Information:
| Substrate Name | Dammarenediol-Ii |
| Substrate Chemical Formula | C30H52O2 |
| Substrate PubChem CID | 10895555 |
| Substrate Smiles | CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1CC[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)C)O)C |
| Substrate Structure |
Product Information:
| Product Name | Protopanaxadiol |
| Product Chemical Formula | C30H52O3 |
| Product PubChem CID | 9920281 |
| Product Smiles | CC(=CCC[C@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)O)C)O)C |
| Product Structure |
References:
| Title: | The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng. |
| PMID: | 22039120 |
| Journal: | Plant & cell physiology |
| Year: | 2011/12/1 |