Detail Information
P450 Protein:
| P450 Symbol | CYP716S1 |
| Protein Name | Protopanaxadiol 6-hydroxylase |
| Uniprot ID | I7CT85 |
| EC Number | 1.14.14.121 |
| Species | Panax ginseng (Korean ginseng) |
| Txid | 4054 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C30H52O3 → C30H52O4 |
| Reaction Type | Oxidation |
| Chemical Bond | CH3 |
CYP716S1
Substrate Information:
| Substrate Name | Protopanaxadiol |
| Substrate Chemical Formula | C30H52O3 |
| Substrate PubChem CID | 9920281 |
| Substrate Smiles | CC(=CCC[C@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)O)C)O)C |
| Substrate Structure |
Product Information:
| Product Name | Protopanaxatriol |
| Product Chemical Formula | C30H52O4 |
| Product PubChem CID | 9847853 |
| Product Smiles | CC(=CCC[C@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(C[C@@H]([C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)O)C)O)C)O)C |
| Product Structure |
References:
| Title: | Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng. |
| PMID: | 22875608 |
| Journal: | Plant & cell physiology |
| Year: | 2012/9/1 |