Detail Information
P450 Protein:
| P450 Symbol | CYP87D18 |
| Protein Name | Cytochrome P450 |
| Uniprot ID | K7NBX0 |
| Species | Siraitia grosvenorii (Monk's fruit) (Luo han guo) |
| Txid | 190515 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein Microsome membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C30H50O2 → C30H48O2 |
| Reaction Type | Oxidation |
| Chemical Bond | CH-OH |
CYP87D18
Substrate Information:
| Substrate Name | 11-Hydroxycucurbitadienol |
| Substrate Chemical Formula | C30H50O2 |
| Substrate PubChem CID | 131801253 |
| Substrate Smiles | C[C@H](CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(C[C@H]([C@@]3([C@H]2CC=C4[C@H]3CC[C@@H](C4(C)C)O)C)O)C)C |
| Substrate Structure |
Product Information:
| Product Name | 11-Oxocucurbitadienol |
| Product Chemical Formula | C30H48O2 |
| Product PubChem CID | 131801254 |
| Product Smiles | C[C@H](CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(CC(=O)[C@@]3([C@H]2CC=C4[C@H]3CC[C@@H](C4(C)C)O)C)C)C |
| Product Structure |
References:
| Title: | Oxidation of Cucurbitadienol Catalyzed by CYP87D18 in the Biosynthesis of Mogrosides from Siraitia grosvenorii. |
| PMID: | 26903528 |
| Journal: | Plant & cell physiology |
| Year: | 2016/5/1 |
| Title: | The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii. |
| PMID: | 27821754 |
| Journal: | Proceedings of the National Academy of Sciences of the United States of America |
| Year: | 2016/11/22 |