Detail Information
P450 Protein:
| P450 Symbol | CYP1A1 |
| Protein Name | Cytochrome P450 1A1 |
| Uniprot ID | P04798 |
| EC Number | 1.14.14.1; 4.2.1.152 |
| Gene ID | 1543 |
| Species | Homo sapiens (Human) |
| Txid | 9606 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein Microsome membrane; Peripheral membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C18H31O4- → C18H29O3- + H2O |
| Reaction Type | Reduction |
| Chemical Bond | O-O |
| RheaID | 48716 |
CYP1A1
+
Substrate Information:
| Substrate Name | (13S)-Hydroperoxy-(9Z,11E)-Octadecadienoate |
| Substrate Chemical Formula | C18H31O4- |
| Substrate PubChem CID | 21158461 |
| Substrate Smiles | CCCCC[C@@H](/C=C/C=CCCCCCCCC(=O)[O-])OO |
| Substrate Structure |
Product Information:
| Product Name | 13-Oxo-(9Z,11E)-Octadecadienoate |
| Product Chemical Formula | C18H29O3- |
| Product PubChem CID | 40490648 |
| Product Smiles | CCCCCC(=O)/C=C/C=CCCCCCCCC(=O)[O-] |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
References:
| Title: | Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids. |
| PMID: | 21068195 |
| Journal: | Drug metabolism and disposition: the biological fate of chemicals |
| Year: | 2011/2/1 |