Detail Information
P450 Protein:
| P450 Symbol | CYP1A2 |
| Protein Name | Cytochrome P450 1A2 |
| Uniprot ID | P05177 |
| EC Number | 1.14.14.1; 4.2.1.152 |
| Gene ID | 1544 |
| Species | Homo sapiens (Human) |
| Txid | 9606 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | / |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C11H11N5 → C11H11N5O |
| Reaction Type | Oxidation |
| Chemical Bond | NH2 |
CYP1A2
Substrate Information:
| Substrate Name | MeIQx |
| Substrate Chemical Formula | C11H11N5 |
| Substrate PubChem CID | 62275 |
| Substrate Smiles | CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)N |
| Substrate Structure |
Product Information:
| Product Name | N-hydroxy-MeIQx |
| Product Chemical Formula | C11H11N5O |
| Product PubChem CID | 115104 |
| Product Smiles | C1C(C)=NC2C3N=C(NO)N(C)C=3C=CC=2N=1 |
| Product Structure |
References:
| Title: | Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2. |
| PMID: | 12351158 |
| Journal: | Mutation research |
| Year: | 2002/9/30 |