Detail Information
P450 Protein:
| P450 Symbol | CYP1A2 |
| Protein Name | Cytochrome P450 1A2 |
| Uniprot ID | A0A8I6AD25 |
| EC Number | 1.14.14.1; 4.2.1.152 |
| Gene ID | 1544 |
| Species | Rattus norvegicus |
| Txid | 10116 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | / |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C13H13ClN4 → C13H12N4O |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP1A2
Substrate Information:
| Substrate Name | PhIP |
| Substrate Chemical Formula | C13H13ClN4 |
| Substrate PubChem CID | 1530 |
| Substrate Smiles | CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1N.Cl |
| Substrate Structure |
Product Information:
| Product Name | 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol |
| Product Chemical Formula | C13H12N4O |
| Product PubChem CID | 15897928 |
| Product Smiles | C1C=C(O)C=CC=1C1=CC2N(C)C(N[H])=NC=2N=C1 |
| Product Structure |
References:
| Title: | Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2. |
| PMID: | 12351158 |
| Journal: | Mutation research |
| Year: | 2002/9/30 |