Detail Information
P450 Protein:
| P450 Symbol | CYP4A10 |
| Protein Name | Cytochrome P450 4A10 |
| Uniprot ID | P08516 |
| EC Number | 1.14.14.80 |
| Gene ID | 50549 |
| Species | Rattus norvegicus (Rat) |
| Txid | 10116 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein Microsome membrane; Multi-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C12H23O2- + C17H21N4O9P-2 + O2 → C12H23O3- + FMN + H2O + H+ |
| Reaction Type | Oxidation |
| Chemical Bond | CH3 |
| RheaID | 38947 |
+
+
CYP4A10
+
+
+
Substrate Information:
| Substrate Name | Dodecanoate |
| Substrate Chemical Formula | C12H23O2- |
| Substrate PubChem CID | 4149208 |
| Substrate Smiles | CCCCCCCCCCCC(=O)[O-] |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | 12-Hydroxydodecanoate |
| Product Chemical Formula | C12H23O3- |
| Product PubChem CID | 9548810 |
| Product Smiles | C(CCCCCC(=O)[O-])CCCCCO |
| Product Structure |
| Product Name | FMN |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors. |
| PMID: | 10362749 |
| Journal: | The American journal of physiology |
| Year: | 1999/6/1 |
| Title: | Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases. |
| PMID: | 10620324 |
| Journal: | Archives of biochemistry and biophysics |
| Year: | 2000/1/1 |
| Title: | Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family. |
| PMID: | 3027069 |
| Journal: | The Journal of biological chemistry |
| Year: | 1987/1/15 |