Detail Information
P450 Protein:
| P450 Symbol | STORR |
| Protein Name | Bifunctional protein STORR |
| Uniprot ID | P0DKI7 |
| EC Number | 1.14.19.54; 1.5.1.27 |
| Species | Papaver somniferum (Opium poppy) |
| Txid | 3469 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein Microsome membrane; Peripheral membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C19H23NO4 + C21H25N7O17P3-3 → C19H22NO4+ + NADPH(4-) + H+ |
| Reaction Type | Oxidation |
| Chemical Bond | CH-N |
| RheaID | 17569 |
+
STORR
+
+
Substrate Information:
| Substrate Name | (R)-Reticuline |
| Substrate Chemical Formula | C19H23NO4 |
| Substrate PubChem CID | 440586 |
| Substrate Smiles | CN1CCC2=CC(=C(C=C2[C@H]1CC3=CC(=C(C=C3)OC)O)O)OC |
| Substrate Structure |
| Substrate Name | NADP+ |
| Substrate Chemical Formula | C21H25N7O17P3-3 |
| Substrate PubChem CID | 162422398 |
| Substrate Smiles | C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)([O-])OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)OP(=O)([O-])[O-])O)O)C(=O)N |
| Substrate Structure |
Product Information:
| Product Name | 1,2-Dehydroreticuline |
| Product Chemical Formula | C19H22NO4+ |
| Product PubChem CID | 440930 |
| Product Smiles | C[N+]1=C(C2=CC(=C(C=C2CC1)OC)O)CC3=CC(=C(C=C3)OC)O |
| Product Structure |
| Product Name | NADPH(4-) |
| Product PubChem CID | 15983949 |
| Product Smiles | C1C=CN(C=C1C(=O)N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)([O-])OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Plant science. Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein. |
| PMID: | 26113639 |
| Journal: | Science (New York, N.Y.) |
| Year: | 2015/7/17 |