Detail Information
P450 Protein:
| P450 Symbol | psiH |
| Protein Name | Tryptamine 4-monooxygenase |
| Uniprot ID | P0DPA7 |
| EC Number | 1.14.99.59 |
| Species | Psilocybe cubensis (Psychedelic mushroom) (Stropharia cubensis) |
| Txid | 181762 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | / |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C10H12N2 + RH2 + O2 → C10H12N2O + A + H2O + H+ |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| RheaID | 15865 |
+
+
psiH
+
+
+
Substrate Information:
| Substrate Name | Tryptamine |
| Substrate Chemical Formula | C10H12N2 |
| Substrate PubChem CID | 1150 |
| Substrate Smiles | C1=CC=C2C(=C1)C(=CN2)CCN |
| Substrate Structure |
| Substrate Name | AH2 |
| Substrate Chemical Formula | RH2 |
| Substrate Smiles | *([H])[H] |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | 4-Hydroxytryptamine |
| Product Chemical Formula | C10H12N2O |
| Product PubChem CID | 11297 |
| Product Smiles | C1=CC2=C(C(=C1)O)C(=CN2)CCN |
| Product Structure |
| Product Name | A |
| Product Smiles | * |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Enzymatic Synthesis of Psilocybin. |
| PMID: | 28763571 |
| Journal: | Angewandte Chemie (International ed. in English) |
| Year: | 2017/9/25 |