Detail Information
P450 Protein:
| P450 Symbol | CYP2C9 |
| Protein Name | Cytochrome P450 2C9 |
| Uniprot ID | P11712 |
| EC Number | 1.14.14.1; 1.14.14.51; 1.14.14.52; 1.14.14.53 |
| Gene ID | 1559 |
| Species | Homo sapiens (Human) |
| Txid | 9606 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C10H16 + C17H21N4O9P-2 + O2 → C10H16O + C17H18N4O9P-3 + H2O + H+ |
| Reaction Type | Oxidation |
| Chemical Bond | CH3 |
| RheaID | 23432 |
+
+
CYP2C9
+
+
+
Substrate Information:
| Substrate Name | (4S)-Limonene |
| Substrate Chemical Formula | C10H16 |
| Substrate PubChem CID | 439250 |
| Substrate Smiles | CC1=CC[C@H](CC1)C(=C)C |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | (4S)-Perillyl Alcohol |
| Product Chemical Formula | C10H16O |
| Product PubChem CID | 369312 |
| Product Smiles | CC(=C)[C@H]1CCC(=CC1)CO |
| Product Structure |
| Product Name | FMN |
| Product Chemical Formula | C17H18N4O9P-3 |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. |
| PMID: | 11950794 |
| Journal: | Drug metabolism and disposition: the biological fate of chemicals |
| Year: | 2002/5/1 |