Detail Information

P450 Protein:

P450 SymbolCYP11B1
Protein NameCytochrome P450 11B1, mitochondrial
Uniprot IDP15538
EC Number1.14.15.4
Gene ID 1584
SpeciesHomo sapiens (Human)
Txid 9606
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location/
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C21H30O4 + Fe2S2 + O2 + H+ → C21H30O5 + Fe2S2 + H2O
Reaction TypeOxidation
Chemical BondCH2
RheaID 46100

11-Deoxycortisol

+

[2Fe-2S]1+

+

O2

+

H+

CYP11B1

Cortisol

+

[2Fe-2S]2+

+

H2O

Substrate Information:

Substrate Name 11-Deoxycortisol
Substrate Chemical FormulaC21H30O4
Substrate PubChem CID440707
Substrate SmilesC[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C
Substrate Structure
Substrate Name [2Fe-2S]1+
Substrate Chemical FormulaFe2S2
Substrate SmilesS1[Fe]S[Fe+]1
Substrate Structure
Substrate Name O2
Substrate Chemical FormulaO2
Substrate PubChem CID977
Substrate CAS Number7782-44-7
Substrate SmilesO=O
Substrate Structure
Substrate Name H+
Substrate Chemical FormulaH+
Substrate PubChem CID1038
Substrate CAS Number12408-02-5
Substrate Smiles[H+]
Substrate Structure

Product Information:

Product Name Cortisol
Product Chemical FormulaC21H30O5
Product PubChem CID5754
Product SmilesC[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
Product Structure
Product Name [2Fe-2S]2+
Product Chemical FormulaFe2S2
Product SmilesS1[Fe+]S[Fe+]1
Product Structure
Product Name H2O
Product Chemical FormulaH2O
Product PubChem CID962
Product CAS Number7732-18-5
Product SmilesO
Product Structure

References:

Title: Purification and functional characterization of human 11beta hydroxylase expressed in Escherichia coli.
PMID: 18215163
Journal: The FEBS journal
Year: 2008/2/1

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics