Detail Information
P450 Protein:
| P450 Symbol | CYP106A1 |
| Protein Name | Cytochrome P450 |
| Uniprot ID | D5DF35 |
| EC Number | 1.14.14.- |
| Species | Priestia megaterium DSM 319 |
| Txid | 592022 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Cytoplasm |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C21H28O5 → C21H28O6 |
| Reaction Type | Oxidation |
| Chemical Bond | CH2 |
CYP106A1
Substrate Information:
| Substrate Name | Cortisone |
| Substrate Chemical Formula | C21H28O5 |
| Substrate PubChem CID | 222786 |
| Substrate Smiles | C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C |
| Substrate Structure |
Product Information:
| Product Name | 6Beta-Hydroxycortisone |
| Product Chemical Formula | C21H28O6 |
| Product PubChem CID | 53674638 |
| Product Smiles | C[C@]12CCC(=O)C=C1[C@@H](C[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O |
| Product Structure |
References:
| Title: | Comparison of CYP106A1 and CYP106A2 from Bacillus megaterium?-?identification of a novel 11-oxidase activity. |
| PMID: | 25904128 |
| Journal: | Applied microbiology and biotechnology |
| Year: | 2015/10/1 |