Detail Information
P450 Protein:
| P450 Symbol | CYP5A1 |
| Protein Name | Thromboxane-A synthase |
| Uniprot ID | P24557 |
| EC Number | 4.2.1.152; 5.3.99.5 |
| Gene ID | 6916 |
| Species | Homo sapiens (Human) |
| Txid | 9606 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H31O4- → C20H29O3- + H2O |
| Reaction Type | Reduction |
| Chemical Bond | O-O |
| RheaID | 55556 |
CYP5A1
+
Substrate Information:
| Substrate Name | A Hydroperoxyeicosatetraenoate |
| Substrate Chemical Formula | C20H31O4- |
| Substrate Structure |
|
|---|
Product Information:
| Product Name | An Oxoeicosatetraenoate |
| Product Chemical Formula | C20H29O3- |
| Product Structure |
|
|---|
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
References:
| Title: | Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases. |
| PMID: | 17459323 |
| Journal: | Archives of biochemistry and biophysics |
| Year: | 2007/5/15 |