Detail Information
P450 Protein:
| P450 Symbol | CYP4F8 |
| Protein Name | Cytochrome P450 4F8 |
| Uniprot ID | P98187 |
| EC Number | 1.14.14.1 |
| Gene ID | 11283 |
| Species | Homo sapiens (Human) |
| Txid | 9606 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein Microsome membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C22H33O2- + C17H21N4O9P-2 + O2 → C22H33O3- + C17H18N4O9P-3 + CHO2- + H2O + H+ |
| Reaction Type | Oxidation |
| Chemical Bond | CH-CH |
| RheaID | 51104 |
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+
CYP4F8
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+
Substrate Information:
| Substrate Name | (7Z,10Z,13Z,16Z,19Z)-Docosapentaenoate |
| Substrate Chemical Formula | C22H33O2- |
| Substrate PubChem CID | 40846589 |
| Substrate Smiles | CC/C=CC/C=CC/C=CC/C=CC/C=CCCCCCC(=O)[O-] |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | 13,14-Epoxy-(7Z,10Z,16Z,19Z)-Docosatetraenoate |
| Product Chemical Formula | C22H33O3- |
| Product PubChem CID | 122391348 |
| Product Smiles | CC/C=CC/C=CCC1C(O1)C/C=CC/C=CCCCCCC(=O)[O-] |
| Product Structure |
| Product Name | FMN |
| Product Chemical Formula | C17H18N4O9P-3 |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | formate |
| Product Chemical Formula | CHO2- |
| Product PubChem CID | 283 |
| Product CAS Number | 71-47-6 |
| Product Smiles | C(=O)[O-] |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8. |
| PMID: | 16112640 |
| Journal: | Archives of biochemistry and biophysics |
| Year: | 2005/9/15 |