Detail Information
P450 Protein:
| P450 Symbol | CYP130A1 |
| Protein Name | Cytochrome P450 130 |
| Uniprot ID | P9WPN5 |
| EC Number | 1.14.-.- |
| Gene ID | 45425226 |
| Species | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Txid | 83332 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | / |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C18H25NO → C17H23NO |
| Reaction Type | Decomposition |
| Chemical Bond | N-CH3 |
CYP130A1
Substrate Information:
| Substrate Name | Dextromethorphan |
| Substrate Chemical Formula | C18H25NO |
| Substrate PubChem CID | 5360696 |
| Substrate Smiles | CN1CC[C@@]23CCCC[C@@H]2[C@@H]1CC4=C3C=C(C=C4)OC |
| Substrate Structure |
Product Information:
| Product Name | 3-Methoxymorphinan |
| Product Chemical Formula | C17H23NO |
| Product PubChem CID | 5484286 |
| Product Smiles | COC1=CC2=C(C[C@@H]3[C@H]4[C@@]2(CCCC4)CCN3)C=C1 |
| Product Structure |
References:
| Title: | Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? |
| PMID: | 30810776 |
| Journal: | Applied microbiology and biotechnology |
| Year: | 2019/5/1 |