Detail Information

P450 Protein:

P450 Symbolcyp51
Protein NameSterol 14alpha-demethylase
Uniprot IDP9WPP9
EC Number1.14.15.36
Gene ID 888819
SpeciesMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Txid 83332
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular LocationCytoplasm
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C30H50O → C29H46O
Reaction TypeOxidation;Decomposition
Chemical BondC-CH3;C-CH2

Obtusifoliol

cyp51

4Alpha-Methyl-5Alpha-Ergosta-8,14,24(28)-Trien-3Beta-Ol

Substrate Information:

Substrate Name Obtusifoliol
Substrate Chemical FormulaC30H50O
Substrate PubChem CID65252
Substrate SmilesC[C@H]1[C@@H]2CCC3=C([C@]2(CC[C@@H]1O)C)CC[C@]4([C@]3(CC[C@@H]4[C@H](C)CCC(=C)C(C)C)C)C
Substrate Structure

Product Information:

Product Name 4Alpha-Methyl-5Alpha-Ergosta-8,14,24(28)-Trien-3Beta-Ol
Product Chemical FormulaC29H46O
Product PubChem CID443237
Product SmilesC[C@H]1[C@@H]2CCC3=C([C@]2(CC[C@@H]1O)C)CC[C@]4(C3=CC[C@@H]4[C@H](C)CCC(=C)C(C)C)C
Product Structure

References:

Title: Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis.
PMID: 10430874
Journal: Proceedings of the National Academy of Sciences of the United States of America
Year: 1999/8/3

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics