Detail Information
P450 Protein:
| P450 Symbol | cyp51 |
| Protein Name | Sterol 14alpha-demethylase |
| Uniprot ID | P9WPP9 |
| EC Number | 1.14.15.36 |
| Gene ID | 888819 |
| Species | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Txid | 83332 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein Microsome membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C30H52O → C29H48O |
| Reaction Type | Decomposition |
| Chemical Bond | CH3 |
cyp51
Substrate Information:
| Substrate Name | 24,25-Dihydrolanosterol |
| Substrate Chemical Formula | C30H52O |
| Substrate PubChem CID | 440560 |
| Substrate Smiles | C[C@H](CCCC(C)C)[C@H]1CC[C@@]2([C@@]1(CCC3=C2CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)C |
| Substrate Structure |
Product Information:
| Product Name | 4,4-Dimethyl-8,14-Cholestadien-3Beta-Ol |
| Product Chemical Formula | C29H48O |
| Product PubChem CID | 167817 |
| Product Smiles | C[C@H](CCCC(C)C)[C@H]1CC=C2[C@@]1(CCC3=C2CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C |
| Product Structure |
References:
| Title: | Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis. |
| PMID: | 10430874 |
| Journal: | Proceedings of the National Academy of Sciences of the United States of America |
| Year: | 1999/8/3 |