Detail Information
P450 Protein:
| P450 Symbol | CYP107A1 |
| Protein Name | 6-deoxyerythronolide B hydroxylase |
| Uniprot ID | Q00441 |
| EC Number | 1.14.15.35 |
| Species | Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) |
| Txid | 405948 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Cytoplasm |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C21H38O6 → C21H38O7 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP107A1
Substrate Information:
| Substrate Name | 6-Deoxyerythronolide B |
| Substrate Chemical Formula | C21H38O6 |
| Substrate PubChem CID | 121904 |
| Substrate Smiles | CC[C@@H]1[C@@H]([C@@H]([C@H](C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O)C)O)C)C)C)O)C |
| Substrate Structure |
Product Information:
| Product Name | Erythronolide B |
| Product Chemical Formula | C21H38O7 |
| Product PubChem CID | 441113 |
| Product Smiles | CC[C@@H]1[C@@H]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O)C)O)(C)O)C)C)O)C |
| Product Structure |
References:
| Title: | Characterization of Saccharopolyspora erythraea cytochrome P-450 genes and enzymes, including 6-deoxyerythronolide B hydroxylase. |
| PMID: | 1732208 |
| Journal: | Journal of bacteriology |
| Year: | 1992/2/1 |
| Title: | An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea. |
| PMID: | 2011746 |
| Journal: | Science (New York, N.Y.) |
| Year: | 1991/4/5 |