Detail Information
P450 Protein:
| P450 Symbol | CYP79A1 |
| Protein Name | Tyrosine N-monooxygenase |
| Uniprot ID | Q43135 |
| EC Number | 1.14.14.36 |
| Gene ID | 8061413 |
| Species | Sorghum bicolor (Sorghum) (Sorghum vulgare) |
| Txid | 4558 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C9H11NO5 + H+ → C8H9NO2 + CO2 + H2O |
| Reaction Type | Oxidoreduction |
| Chemical Bond | CH-NH2;Carboxyl |
| RheaID | 23044 |
+
CYP79A1
+
+
Substrate Information:
| Substrate Name | N,N-dihydroxy-L-tyrosine |
| Substrate Chemical Formula | C9H11NO5 |
| Substrate PubChem CID | 5461147 |
| Substrate Smiles | C1=CC(=CC=C1C[C@@H](C(=O)O)N(O)O)O |
| Substrate Structure |
| Substrate Name | H+ |
| Substrate Chemical Formula | H+ |
| Substrate PubChem CID | 1038 |
| Substrate CAS Number | 12408-02-5 |
| Substrate Smiles | [H+] |
| Substrate Structure |
Product Information:
| Product Name | (E)-4-Hydroxyphenylacetaldehyde Oxime |
| Product Chemical Formula | C8H9NO2 |
| Product PubChem CID | 5460411 |
| Product Smiles | C1=CC(=CC=C1C/C=N/O)O |
| Product Structure |
| Product Name | CO2 |
| Product Chemical Formula | CO2 |
| Product PubChem CID | 280 |
| Product CAS Number | 124-38-9 |
| Product Smiles | O=C=O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
References:
| Title: | Isolation of the heme-thiolate enzyme cytochrome P-450TYR, which catalyzes the committed step in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench. |
| PMID: | 7937883 |
| Journal: | Proceedings of the National Academy of Sciences of the United States of America |
| Year: | 1994/10/11 |