Detail Information
P450 Protein:
| P450 Symbol | CYP105A3 |
| Protein Name | Cytochrome P450 105A3 |
| Uniprot ID | Q59831 |
| EC Number | 1.14.-.- |
| Species | Streptomyces carbophilus |
| Txid | 44059 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | / |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C23H34O5 → C23H36O7 |
| Reaction Type | Oxidation |
| Chemical Bond | CH3 |
CYP105A3
Substrate Information:
| Substrate Name | Mevastatin |
| Substrate Chemical Formula | C23H34O5 |
| Substrate PubChem CID | 64715 |
| Substrate Smiles | CC[C@H](C)C(=O)O[C@H]1CCC=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O |
| Substrate Structure |
Product Information:
| Product Name | Pravastatin |
| Product Chemical Formula | C23H36O7 |
| Product PubChem CID | 54687 |
| Product Smiles | CC[C@H](C)C(=O)O[C@H]1C[C@@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)O)O)O)O |
| Product Structure |
References:
| Title: | A two component-type cytochrome P-450 monooxygenase system in a prokaryote that catalyzes hydroxylation of ML-236B to pravastatin, a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. |
| PMID: | 1905157 |
| Journal: | Biochimica et biophysica acta |
| Year: | 1991/6/19 |
| Title: | Cloning, characterization and expression of the gene encoding cytochrome P-450sca-2 from Streptomyces carbophilus involved in production of pravastatin, a specific HMG-CoA reductase inhibitor. |
| PMID: | 7557483 |
| Journal: | Gene |
| Year: | 1995/9/22 |