Detail Information
P450 Protein:
| P450 Symbol | CYP105A3 |
| Protein Name | Cytochrome P450 105A3 |
| Uniprot ID | Q59831 |
| EC Number | 1.14.-.- |
| Species | Streptomyces carbophilus |
| Txid | 44059 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | / |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C23H35NaO6 → C23H35NaO7 |
| Reaction Type | Oxidation |
| Chemical Bond | CH2 |
CYP105A3
Substrate Information:
| Substrate Name | Mevastatin Sodium |
| Substrate Chemical Formula | C23H35NaO6 |
| Substrate PubChem CID | 16760562 |
| Substrate Smiles | CC[C@H](C)C(=O)O[C@H]1CCC=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)[O-])O)O.[Na+] |
| Substrate Structure |
Product Information:
| Product Name | Pravastatin Sodium |
| Product Chemical Formula | C23H35NaO7 |
| Product PubChem CID | 16759173 |
| Product Smiles | CC[C@H](C)C(=O)O[C@H]1C[C@@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)[O-])O)O)O.[Na+] |
| Product Structure |
References:
| Title: | Semi-rational engineering of cytochrome P450sca-2 in a hybrid system for enhanced catalytic activity: insights into the important role of electron transfer. |
| PMID: | 23737252 |
| Journal: | Biotechnology and bioengineering |
| Year: | 2013/11/1 |