Detail Information
P450 Protein:
| P450 Symbol | cyp199a2 |
| Protein Name | Cytochrome p450 CYP199A2 |
| Uniprot ID | Q6N8N2 |
| EC Number | 1.14.99.15 |
| Gene ID | 66892909 |
| Species | Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) |
| Txid | 258594 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Cytoplasm |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C8H7O3- + RH2 + O2 → C7H5O3- + CH2O + R + H2O |
| Reaction Type | Decomposition |
| Chemical Bond | OCH3 |
| RheaID | 18613 |
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cyp199a2
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Substrate Information:
| Substrate Name | 4-Methoxybenzoate |
| Substrate Chemical Formula | C8H7O3- |
| Substrate PubChem CID | 3783514 |
| Substrate Smiles | COC1=CC=C(C=C1)C(=O)[O-] |
| Substrate Structure |
| Substrate Name | AH2 |
| Substrate Chemical Formula | RH2 |
| Substrate Smiles | *([H])[H] |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | 4-Hydroxybenzoate |
| Product Chemical Formula | C7H5O3- |
| Product PubChem CID | 54675830 |
| Product Smiles | C1=CC(=CC=C1C(=O)O)[O-] |
| Product Structure |
| Product Name | formaldehyde |
| Product Chemical Formula | CH2O |
| Product PubChem CID | 712 |
| Product Smiles | C=O |
| Product Structure |
| Product Name | A |
| Product Chemical Formula | R |
| Product Smiles | * |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
References:
| Title: | Cytochrome P450 enzymes from the metabolically diverse bacterium Rhodopseudomonas palustris. |
| PMID: | 16472768 |
| Journal: | Biochemical and biophysical research communications |
| Year: | 2006/3/31 |
| Title: | Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris. |
| PMID: | 18762195 |
| Journal: | Journal of molecular biology |
| Year: | 2008/11/14 |