Detail Information
P450 Protein:
| P450 Symbol | CYP725A4 |
| Protein Name | Taxadiene 5-alpha hydroxylase |
| Uniprot ID | Q6WG30 |
| EC Number | 1.14.14.176 |
| Species | Taxus cuspidata (Japanese yew) |
| Txid | 99806 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H32 → C20H32O |
| Reaction Type | Oxidation |
| Chemical Bond | CH2 |
CYP725A4
Substrate Information:
| Substrate Name | Taxadiene |
| Substrate Chemical Formula | C20H32 |
| Substrate PubChem CID | 443484 |
| Substrate Smiles | CC1=C2CC[C@@]3(CCC=C([C@H]3C[C@@H](C2(C)C)CC1)C)C |
| Substrate Structure |
Product Information:
| Product Name | Taxadien-5Alpha-Ol |
| Product Chemical Formula | C20H32O |
| Product PubChem CID | 443485 |
| Product Smiles | C(C)1=C2CC[C@@](C)3CC[C@H](O)C(=C)[C@@]3([H])C[C@@]([H])(C2(C)C)CC1 |
| Product Structure |
References:
| Title: | Recent developments in the application of P450 based biocatalysts. |
| PMID: | 29100098 |
| Journal: | Current opinion in chemical biology |
| Year: | 2018/4/1 |