Detail Information
P450 Protein:
| P450 Symbol | CYP2U1 |
| Protein Name | Cytochrome P450 2U1 |
| Uniprot ID | Q7Z449 |
| EC Number | 1.14.14.80 |
| Gene ID | 113612 |
| Species | Homo sapiens (Human) |
| Txid | 9606 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein Microsome membrane; Multi-pass membrane protein Mitochondrion inner membrane; Multi-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C30H42N2O2 + C17H21N4O9P-2 + O2 → C30H42N2O3 + C17H18N4O9P-3 + H2O + H+ |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| RheaID | 50296 |
+
+
CYP2U1
+
+
+
Substrate Information:
| Substrate Name | N-[(5Z,8Z,11Z,14Z)-Eicosatetraenoyl]-Serotonin |
| Substrate Chemical Formula | C30H42N2O2 |
| Substrate PubChem CID | 10027372 |
| Substrate Smiles | CCCCC/C=CC/C=CC/C=CC/C=CCCCC(=O)NCCC1=CNC2=C1C=C(C=C2)O |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | 2-Oxo-N-[(5Z,8Z,11Z,14Z)-Eicosatetraenoyl]-Serotonin |
| Product Chemical Formula | C30H42N2O3 |
| Product PubChem CID | 121225536 |
| Product Smiles | CCCCC/C=CC/C=CC/C=CC/C=CCCCC(=O)NCCC1C2=C(C=CC(=C2)O)NC1=O |
| Product Structure |
| Product Name | FMN |
| Product Chemical Formula | C17H18N4O9P-3 |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Oxidation of endogenous N-arachidonoylserotonin by human cytochrome P450 2U1. |
| PMID: | 24563460 |
| Journal: | The Journal of biological chemistry |
| Year: | 2014/4/11 |