Detail Information

P450 Protein:

P450 SymbolCYP725A2
Protein NameTaxane 13-alpha-hydroxylase
Uniprot IDQ8W4T9
EC Number1.14.14.106
SpeciesTaxus cuspidata (Japanese yew)
Txid 99806
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location/
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C20H32O → C20H32O2
Reaction TypeOxidation
Chemical BondCH2

5Alpha-Hydroxy Taxadience

CYP725A2

5Alpha,13Alpha-Dihydroxy Taxadience

Substrate Information:

Substrate Name 5Alpha-Hydroxy Taxadience
Substrate Chemical FormulaC20H32O
Substrate Smiles[C@](C)(C)1C2=C(C)CC[C@]1([H])C[C@@]([H])1C(=C)[C@@H](O)CC[C@@]1(C)CC2
Substrate Structure

Product Information:

Product Name 5Alpha,13Alpha-Dihydroxy Taxadience
Product Chemical FormulaC20H32O2
Product Smiles[C@](C)(C)1C2=C(C)[C@@H](O)C[C@]1([H])C[C@@]([H])1C(=C)[C@@H](O)CC[C@@]1(C)CC2
Product Structure

References:

Title: Taxoid metabolism: Taxoid 14beta-hydroxylase is a cytochrome P450-dependent monooxygenase.
PMID: 12729625
Journal: Archives of biochemistry and biophysics
Year: 2003/5/15

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
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