Detail Information
P450 Protein:
| P450 Symbol | CYP707A1 |
| Protein Name | Abscisic acid 8'-hydroxylase 1 |
| Uniprot ID | Q949P1 |
| EC Number | 1.14.14.137 |
| Gene ID | 827663 |
| Species | Arabidopsis thaliana (Mouse-ear cress) |
| Txid | 3702 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C15H19O4- + C17H21N4O9P-2 + O2 → C15H19O5- + C17H18N4O9P-3 + H2O + H+ |
| Reaction Type | Oxidation |
| Chemical Bond | CH3 |
| RheaID | 12897 |
+
+
CYP707A1
+
+
+
Substrate Information:
| Substrate Name | 2-Cis-(+)-Abscisate |
| Substrate Chemical Formula | C15H19O4- |
| Substrate PubChem CID | 7251168 |
| Substrate Smiles | CC1=CC(=O)CC([C@]1(/C=C/C(=CC(=O)[O-])/C)O)(C)C |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | (+)-8′-Hydroxyabscisate |
| Product Chemical Formula | C15H19O5- |
| Product PubChem CID | 25245404 |
| Product Smiles | CC1=CC(=O)C[C@]([C@]1(/C=C/C(=CC(=O)[O-])/C)O)(C)CO |
| Product Structure |
| Product Name | FMN |
| Product Chemical Formula | C17H18N4O9P-3 |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Arabidopsis CYP707As encode (+)-abscisic acid 8'-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid. |
| PMID: | 15064374 |
| Journal: | Plant physiology |
| Year: | 2004/4/1 |